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Victoria C Ward, Yingjie Weng, Jason Bentley, Suzan L Carmichael, Kala M Mehta, Wajeeha Mahmood, Kevin T Pepper, Safa Abdalla, Yamini Atmavilas, Tanmay Mahapatra, Sridhar Srikantiah, Evan Borkum, Anu Rangarajan, Swetha Sridharan, Dana Rotz, Debarshi Bhattacharya, Priya Nanda, Usha Kiran Tarigopula, Hemant Shah, Gary L Darmstadt, and for the Ananya Study GroupAtmavilasYaminiBhattacharyaDebarshiBentleyJasonBorkumEvanCarmichaelSuzanChaudhuriIndrajitCreangaAndreeaDarmstadtGary L.DuttPriyankaIraniLailiMahapatraTanmayMehtaKala M.MitraRadharaniMunarWolfgang A.NandaPriyaPepperKevin T.RaheelHinaRangarajanAnuSaggurtiNiranjanSastryPadmapriyaShahHemantSrikantiahSridharTarigopulaUsha KiranWardVictoriaWengYingjieWalkerDilysWilhelmJess

Abstract

Background

Despite increasing focus on health inequities in low- and middle income countries, significant disparities persist. We analysed impacts of a statewide maternal and child health program among the most compared to the least marginalised women in Bihar, India.

Methods

Utilising survey-weighted logistic regression, we estimated programmatic impact using difference-in-difference estimators from Mathematica data collected at the beginning (2012, n = 10 174) and after two years of program implementation (2014, n = 9611). We also examined changes in disparities over time using eight rounds of Community-based Household Surveys (CHS) (2012-2017, n = 48 349) collected by CARE India.

Results

At baseline for the Mathematica data, least marginalised women generally performed desired health-related behaviours more frequently than the most marginalised. After two years, most disparities persisted. Disparities increased for skilled birth attendant identification [+16.2% (most marginalised) vs +32.6% (least marginalized), P < 0.01) and skin-to-skin care (+14.8% vs +20.4%, P < 0.05), and decreased for immediate breastfeeding (+10.4 vs -4.9, P < 0.01). For the CHS data, odds ratios compared the most to the least marginalised women as referent. Results demonstrated that disparities were most significant for indicators reliant on access to care such as delivery in a facility (OR range: 0.15 to 0.48) or by a qualified doctor (OR range: 0.08 to 0.25), and seeking care for complications (OR range: 0.26 to 0.64).

Conclusions

Disparities observed at baseline generally persisted throughout program implementation. The most significant disparities were observed amongst behaviours dependent upon access to care. Changes in disparities largely were due to improvements for the least marginalised women without improvements for the most marginalised. Equity-based assessments of programmatic impacts, including those of universal health approaches, must be undertaken to monitor disparities and to ensure equitable and sustainable benefits for all.

Study registration

ClinicalTrials.gov number NCT02726230


With the transition from the Millennium Development Goals to the Sustainable Development Goals (SDGs), equity and the mandate to “leave no one behind” has become central to the global health agenda [1]. A call to “reduce inequality within and among countries” was explicitly articulated in the SDGs alongside the ambitious target of universal coverage of health services [2]. Similarly, the Addis Ababa Declaration of 2012 called for the promotion of equity in all health interventions globally, “to achieve the highest possible standards of health for all” [3]. Thus, in the SDG era, increasing attention is being paid to the monitoring of inequities and social determinants of health when evaluating the impact of global health interventions.

Health inequities have been found to be particularly large in reproductive, maternal, newborn and child health and nutrition (RMNCHN) services in low- and middle-income counties (LMICs) [4-6]. Research focused on evaluating inequities in population coverage of key evidence-based RMNCHN interventions in LMICs [7-9] demonstrates major differences in coverage and impact across population sub-groups; coverage of key health services remains low for the most marginalised groups [5]. Intersecting factors such as gender, early age of marriage, caste, religion and socioeconomic status have all been shown to moderate the utilisation of health services and the impact of interventions [10]. When evaluating the differential impacts of programs, multiple studies have shown that while important advances have been made in equity for exclusive breastfeeding and immunisation coverage [11,12], significant gaps remain, especially for interventions that rely on access to facility-based care such as skilled birth attendance and antenatal care (ANC) visits [13].

Despite the importance of reducing inequities in RMNCHN services in LMICs, especially for reductions in maternal and child mortality [14], few studies have rigorously evaluated changes in inequity from multi-dimensional interventions at scale. To address this evidence gap, we undertook an equity analysis of a statewide, six-year RMNCHN program (2012-2017) in Bihar, India.

METHODS

Study setting and context

In 2009, India accounted for 20% of the world’s population and a disproportionately high percentage of global maternal deaths [15,16]. India also had high measures of income inequality, as reflected by the GINI Index [17]. Bihar is among India’s most populous states with an estimated 104 million people and some of the highest rates of poverty (39% below the poverty line) and illiteracy (about 63% among females) in the world [18]. In 2006, the National Family Health Survey (NFHS-3) showed that rates of key RMNCHN-related health behaviours were also exceedingly low including ≥4 ANC visits (11%), institutional deliveries (20%), exclusive breastfeeding (28%) and contraceptive prevalence rate (34%) (Table S1 in the Online Supplementary Document) [18].

Against this backdrop, the Bill and Melinda Gates Foundation (BMGF) funded the development and implementation of a RMNCHN program called Ananya. The program promoted innovations in interventions and delivery platforms with the goal of supporting the government to improve the quality, uptake and equity of key health behaviours amongst women in Bihar, as described previously [19]. Innovations in intervention delivery designed by non-governmental organisation (NGO) partners were piloted in governmental health systems in eight districts, representing approximately one-quarter of Bihar’s population (28 million) with a plan to support the Government of Bihar (GoB) to scale up successful solutions across all 38 districts and 104 million people.

Objective

We undertook an equity analysis to test the hypothesis that the health impacts of the program would not differ for those women who were most marginalised compared to those who were least marginalised, given the program’s intent to achieve universal coverage. We analysed two distinct sources of data, and utilised an intersectionality approach described by Sen et al [20] in order to understand the ways in which multiple causes of marginalisation influence health impacts. To discern whether the program led to increased or decreased equity in health-related behaviours [19], we set out to examine whether: 1) there were disparities in indicators at baseline; and 2) the disparities changed over the course of the program during the piloting and scale-up phases.

Data sources and study population

Data sources for this study included Mathematica evaluation data and Community-based Household Surveys (CHS).

Mathematica data

Mathematica implemented a statewide household evaluation at two time points: January through April 2012 (“baseline”) and January through April 2014 (“midline”), as described previously [21]. Survey data were collected from maternal household respondents in the eight focus districts of implementation as well as the 30 districts where Ananya was not implemented as a comparison. In both survey rounds, Mathematica conducted a listing to identify women who had given birth in the previous 12 months (about 13 women per village, on average). Thus, the 2012 (n = 10 174) and 2014 (n = 9611) surveys represented repeated cross-sections of mothers. Surveys focused on children ages 0-11 months because health interventions were targeted most intensively on pregnancy and on infant health in the first year after delivery. We excluded women who lived in urban areas (18%), given the significant differences between rural and urban wealth indices including ownership of household assets, household construction materials and sources of drinking water. Figure 1, Panel A provides a study flow diagram for the Mathematica data.

Figure 1.  Study flow diagrams. Panel A. Mathematica surveys, Bihar, India, 2012 and 2014. Panel B. CHS surveys, Bihar, India, 2012-2017.
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CHS data

The CHS data were collected across nine rounds of a household survey for community-based program monitoring, as described previously [22]. The surveys were designed to be a monitoring tool for CARE India and GoB staff to provide district-level point estimates, as well as block-level pass/fail results for a range of indicators at the household level. A design sampling methodology similar to “Lot Quality Assurance Sampling” was used in rounds 2 to 5 (phase I) and a modified version, “Lot Quality Assurance Sampling plus,” was applied in rounds 6 to 9 (phase II) [23]. We excluded round one, as it was a pilot survey to establish the methodology. Rounds 2 to 9 of the surveys were carried out between 2012 and the end of 2017. Phase I of the surveys (rounds 2 to 5) overlapped with the Mathematica evaluation period and with the eight-district pilot phase of implementation. Program scale up began between rounds five and six, and Phase II surveys (rounds 6 to 9) were conducted during the period when governmental implementation was extended statewide to all 38 districts with technomanagerial support of the Bihar Technical Support Program [19]) We included maternal respondents in the eight focus districts where data were available across all rounds (2 to 9) of the surveys. Figure 1, Panel B provides a study flow diagram for the CHS data.

Study outcomes

Indicators, selected prior to analysis, were pertinent to interventions across the continuum of care, relevant to health disparities, and comparable with other analyses reported previously [21,22]. For each continuum of care domain – including antenatal, delivery, postnatal, family planning, immunisation and nutrition – we further classified the indicators by delivery platform. This included frontline worker (FLW) performance or behaviour, mother’s behaviour, and facility care and outreach service delivery, as described previously [19,21,22]. Our aim was to characterise program impact based on continuum of care domains and delivery platforms in order to examine trends for subgroups of indicators relevant to program implementation (Table 1). Indicators were chosen prior to analysis by three independent members of the Stanford analytic team with expertise in maternal and child health and the conduct of field trials. This process yielded 19 indicators for analysis, 18 and 15 of which were available in the CHS data and the Mathematica data, respectively.

Table 1.  Reproductive, maternal, newborn and child health and nutrition indicators by continuum of care domains (rows) and intervention delivery platforms (columns) for the Mathematica and Community-based Household Survey data
FLW performance or behaviour Mother’s behaviour Facility outreach / service delivery
Antenatal care • Received iron-folic acid • Pregnancy registration
• Sought care for complications • 4+ antenatal care visits
Birth preparedness • Arranged transportation to facility
• Identified skilled birth attendant
Family planning • FLW advised sterilisation
• FLW advised PPIUD post-delivery
Delivery • FLW advised handwashing by delivery attendant • Qualified doctor conducted facility delivery
• Facility (public or private) delivery
Postnatal care • FLW visited day or next day after delivery/return from hospital
• FLW advised skin-to skin care • Skin-to-skin care
Complementary feeding/nutrition • FLW advised exclusive breastfeeding • Initiation of complementary feeding • Immediate breastfeeding
Immunisation • DPT3 by card

DPT – diphtheria, pertussis, tetanus, FLW – frontline worker, PPIUD – postpartum intrauterine device



Equity domains

Given the well-known impacts of socioeconomic status and class on health outcomes [24,25], we defined equity domains based on the intersectionality of wealth tertiles and three Indian caste categories: Scheduled Caste/Scheduled Tribe (SCST), Other Backward Caste, and General/Other [20]. Caste was recorded during both CHS and Mathematica surveys (Figure S1 in the Online Supplementary Document). We created wealth indices from information collected by Mathematica and CHS for household assets, house construction materials, source of drinking water and education using principal component analysis (PCA), patterned after the National Family Health Survey (NFHS)-4 wealth index for rural areas [26]. For CHS rounds 2 to 5, a shorter list of items was available, similar to those used in the NFHS-3 wealth index (Table S2 in the Online Supplementary Document) [18,27]. This approach allowed us to maximise the number of items used to generate a wealth index while being as consistent as possible across the two data sources and with existing NFHS wealth indices. Table S3 in the Online Supplementary Document lists the items used in PCA by data source, and compares the loading factors for each item for each index (Mathematica, CHS rounds 2 to 5, and CHS rounds 6 to 9) compared with NFHS-3 and NFHS-4 rural. For analysis, we divided the wealth scores into tertiles. We then created a 9-level variable from the intersection of the three caste categories and the wealth tertiles. We refer to the two, clearly identified extreme groups – SCST/Wealth Tertile 1 and General-Other/Wealth Tertile 3 – as the most and least marginalised, respectively; comparison of these groups was the focus of our analysis.

Analysis

We first described the demographic characteristics of women by data source, overall and among the least and most marginalised women.

Mathematica data

Using Mathematica data, we set out to assess whether there were disparities in health-related behaviours between the least and most marginalised groups at baseline. We then examined differences in program impact on RMNCHN health-related behaviours between the two groups by estimating separate survey logistic regressions for each group. Each survey-weighted logistic regression included an interaction term between the eight focus (intervention) districts (compared to the 30 non-focus districts as referent) and survey time (with baseline as referent), yielding a difference-in-difference (DID) estimator of program impact which corresponds to the interaction term. Models were adjusted for women’s age and gender of the focal child. The survey-weighted logistic regressions also included stratum and sampling weights at the village level (primary sampling unit) and used finite population corrections. As all covariates used in adjustment were included as categorical variables, any missing values were included as a level in the variable. We report the DID as an absolute percentage point change for each group and provide its P-value. In addition, we assessed whether the estimated DIDs were different between the most and least marginalised groups by fitting a combined model for both groups and adding a three-way interaction term between treatment group (focus or comparison districts), survey time (baseline or midline) and equity group (most or least marginalised). We applied a Benjamini-Hochberg False Discovery Rate (FDR) correction to this set of P values to account for multiple testing [28].

CHS data

In order to assess the equity impacts over time, we examined the CHS data set to compare the indicators between the least and most marginalised groups for each survey round (2 to 9). To do so, for each indicator we estimated a separate survey logistic regression for each round that included the intersection variable (ie, most vs least marginalised), mothers’ age, and gender of the focal child. The survey logistic regressions also included sample weights for each block (sampling stratum), where sample weights were the inverse of the number of women sampled divided by the eligible block population. Block populations were derived from Census rural block population estimates and crude birth rates [16,29]. We report both absolute rates with 95% confidence intervals (CIs) for indicators for the most and least marginalised as well as odds ratios (ORs) comparing the two groups. We also applied a Benjamini-Hochberg false discovery ate (FDR) correction to this set of P-values [28].

To assess whether changes in the ORs over time were different for the most vs least marginalised groups for each indicator, we examined an additional survey-weighted logistic regression model that included round (as an ordinal variable), the intersection variable, and an interaction term between round and the intersection variable, adjusted for mother’s age and gender of the focal child. Three sets of models were fit, one using data from all rounds, the second using pilot Phase 1 rounds 2 to 5, and the third using scale-up Phase 2 rounds 6 to 9, so that linear trends in the equity estimates could be evaluated for all rounds, as well as separately in phase I pilot phase and the phase II statewide scale-up period, as described previously [22]. A Benjamini-Hochberg correction was similarly applied to the P values for all ORs to account for multiple testing [28]. Statistical analyses were performed using SAS 9.4 and R 3.4.3 (IBM Inc, Armonk, NY, USA).

Ethical considerations

Permission for access and terms of CHS data use were agreed upon with CARE India through a data sharing agreement. Analysis of CHS and Mathematica data was approved by the Stanford University Institutional Review Board protocol 39719. This study is part of the Ananya program which was registered with ClinicalTrials.gov number NCT02726230.

RESULTS

Study population demographics

The final cohort for analysis included 19 785 women from two Mathematica surveys (baseline, midline) and 48 349 women from eight rounds of CHS (Figure 1). Women respondents on average had similar proportions of illiteracy, no schooling, >2 children in the household, and male focal children in the Mathematica and the CHS cohorts (Table 2). There were lower proportions of large households (46.5% vs 69.3%) and non-nuclear families (44.9% vs 61.6%) in the Mathematica compared to the CHS data.

Table 2.  Demographic characteristics of maternal respondents in the Mathematica and Community-based Household Surveys (CHS) by least and most marginalised groups in Bihar, India
Mathematica – baseline (2012) and midline (2014) CHS (rounds 2 to 9, 2012-2017)
All Least Marginalised* Most Marginalised† All Least Marginalised* Most Marginalised †
No. 19785 1279 (6.5%) 2681 (13.6%) 48349 3082 (6.4%) 6110 (12.6%)
Age, years:
<21 2394 (12.1) 142 (11.1) 308 (11.5) 8477 (17.5) 438 (14.2) 1027 (16.8)
21-25 9385 (47.4) 698 (54.6) 1125 (42.0) 23 023 (47.6) 1685 (54.7) 2610 (42.7)
26-30 6014 (30.4) 368 (28.8) 896 (33.4) 12 627 (26.1) 750 (24.3) 1756 (28.7)
31-35 1413 (7.1) 52 (4.1) 239 (8.9) 3292 (6.8) 170 (5.5) 536 (8.8)
>35 578 (2.9) 19 (1.5) 113 (4.2) 930 (1.9) 39 (1.3) 181 (3)
Literacy:
Illiterate 11784 (59.6) 218 (17.0) 2309 (86.1) 29 340 (60.7) 609 (19.8) 5436 (89)
Literate 8001 (40.4) 1061 (83.0) 372 (13.9) 19 009 (39.3) 2473 (80.2) 674 (11)
Hindu 18044 (91.2) 1253 (98.0) 2671 (99.6) 42 212 (87.3) 2333 (75.7) 6011 (98.4)
Women’s education status:
No schooling 11492 (58.1) 203 (15.9) 2274 (84.8) 29 457 (60.9) 620 (20.1) 5447 (89.1)
Some schooling 8293 (41.9) 1076 (84.1) 407 (15.2) 18 889 (39.1) 2461 (79.9) 662 (10.8)
Had a BPL card 11763 (59.5) 514 (40.2) 1779 (66.4)
Nuclear family:
No 8885 (44.9) 775 (60.6) 777 (29.0) 29 791 (61.6) 2430 (78.8) 2674 (43.8)
Yes 9222 (46.6) 360 (28.1) 1691 (63.1) 18 558 (38.4) 652 (21.2) 3436 (56.2)
Missing 1678 (8.5) 144 (11.3) 213 (7.9) 0 (0) 0 (0) 0 (0)
Small household (household size ≤5):
No 9195 (46.5) 628 (49.1) 1087 (40.5) 33 495 (69.3) 2305 (74.8) 3683 (60.3)
Yes 8912 (45.0) 507 (39.6) 1381 (51.5) 14 854 (30.7) 777 (25.2) 2427 (39.7)
Missing 1678 (8.5) 144 (11.3) 213 (7.9) 0 (0) 0 (0) 0 (0)
Number of children in the household at end:
1 6106 (30.9) 559 (43.7) 677 (25.3) 13 262 (27.4) 1158 (37.6) 1318 (21.6)
2 5458 (27.6) 404 (31.6) 663 (24.7) 12 965 (26.8) 998 (32.4) 1431 (23.4)
3 3955 (20.0) 196 (15.3) 560 (20.9) 9944 (20.6) 518 (16.8) 1339 (21.9)
4+ 4266 (21.6) 120 (9.4) 781 (29.1) 12 178 (25.2) 408 (13.2) 2022 (33.1)
Gender of the focal child:
Female 9346 (47.2) 561 (43.9) 1311 (48.9) 23 095 (47.8) 1438 (46.7) 3046 (49.9)
Male 10 439 (52.8) 718 (56.1) 1370 (51.1) 25 254 (52.2) 1644 (53.3) 3064 (50.1)

BPL – below poverty line

*Least marginalised, defined as General/Other/highest wealth tertile.

†Most margnisalised defined as Scheduled caste/Scheduled trive (SCST)/lowest wealth tertile.



Equity group distributions and characteristics

The overall proportions of the study cohorts that were in the most marginalised group (13.6% and 12.6%) and the least marginalised group (6.5% and 6.4%) were similar for the Mathematica and CHS data, respectively (Table 2). For Mathematica data, the proportion in the most marginalised group was similar at baseline (13.3%) and midline (13.8%), while the least marginalised group increased slightly from baseline (5.7%) to midline (7.3%). Across CHS rounds, the most marginalised group varied between 8.8% to 16.5%, while the proportion of the cohort that was least marginalised generally remained the same (6%-7% across rounds). Examination of proportions of women classified as belonging to the most or least marginalised group for strata under each demographic variable showed consistent patterns across data sources (Figure 2). For women ages 21 and above, there was a general trend for increasing rates of women belonging to the most marginalised group with increasing age. Belonging to the most marginalised group was strongly associated with illiteracy and lack of education. A nuclear family, small household and an increasing number of children were all associated with increased likelihood of being in the most marginalised group. A female focal child was more likely to have a mother in the most marginalised group. Absolute rates of those in the most and least marginalised groups by characteristics were consistent between Mathematica and CHS data, with typically less than ± 5% relative deviation.

Figure 2.  Comparisons of maternal respondents’ demographics by least vs most marginalised group for Mathematica (2012, 2014) and Community-based Household Surveys (CHS) data (2012-2017), Bihar, India.
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Program impacts on equity by continuum of care domain

Mathematica data

Among the 15 indicators assessed using the baseline Mathematica data, we found that the least marginalised women generally performed health-related behaviours at a higher frequency across most indicators than the most marginalised, demonstrating that significant disparity existed at baseline favouring the least marginalised (Table 3). This was true across antenatal care, birth preparedness, delivery, immunisation and nutrition domains; the only exceptions were indicators for pregnancy registration and initiation of complementary feeding, which were similar for least and most marginalised women. The two groups showed similar frequencies across postnatal care indicators. Programmatic impact was significantly different for the most vs the least marginalised groups for some indicators after adjustment for multiple testing (ie, the difference in DIDs had P < 0.05), but for most indicators the disparity remained generally the same. For two indicators (Table 3), a lower increase was seen in focal districts from baseline to midline for the most marginalised compared to the least marginalised group, reflecting an increase in disparity during the program period. These indicators were: identification of a skilled birth attendant [+16.2% (most marginalised) vs +32.6% (least marginalized), P < 0.01) and skin-to-skin care (+14.8% vs +20.4%, P < 0.05). Of note, there was no significant change in disparity for advice given by a FLW regarding skin-to-skin care. For delivery in a facility, the most marginalised demonstrated a -1% decrease during the program period while the least marginalised demonstrated a +10.9% increase; however, these results were not statistically significant (P = 0.083). A closing of the equity gap was found for two indicators (Table 3) wherein the most marginalised in the focus districts demonstrated a significantly greater increase than the least marginalised: receipt of three doses of diptheria-pertussis-tetanus vaccine (DPT3) (-4.9% vs +3.5% for the least vs the most marginalised, respectively, P < 0.01%) and immediate breastfeeding (-4.9% vs +10.4% for the least vs the most marginalised, respectively, P < 0.01). For the former, the equity gap significantly closed, while for the latter, the equity gap was reversed.

Table 3.  Comparison of Ananya pilot and scale-up program impact between least and most marginalised women based on Mathematica data, 2012 and 2014, Bihar, India
Indicator domain and indicator description Equity group Baseline Midline Difference-in-Difference (DID) estimate P-value comparing DID estimates for least and most marginalised groups*,† Result on equity
Focal Non-focal Focal Non-focal
Antenatal care (ANC)
4+ antenatal care (ANC) visits Least marginalised 51% 47% 49% 51% -6.7% 0.690
Most marginalised 35% 34% 33% 26% 5.4%
Identified skilled birth attendant Least marginalised 75% 68% 100% 60% 32.6% <0.01 Widening of equity gap
Most marginalised 50% 48% 65% 47% 16.2%
Arranged transportation Least marginalised 50% 46% 20% 16% -0.1% 0.369
Most marginalised 3% 8% 7% 6% 6.7%
Pregnancy registration Least marginalised 71% 66% 73% 69% -2.5% 0.711
Most marginalised 80% 83% 87% 93% -2.5%
Received ≥90 iron-folic acid tablets Least marginalised 24% 28% 16% 20% -0.4% 0.200
Most marginalised 13% 13% 15% 18% -3.6%
Delivery
Place of delivery: In a facility (public or private) Least marginalised 81% 84% 93% 85% 10.9% 0.083
Most marginalised 53% 47% 62% 58% -1.0%
Qualified doctor conducted facility delivery Least marginalised 38% 36% 37% 28% 6.7% 0.369
Most marginalised 11% 11% 12% 8% 4.8%
Immunisation
DPT3‡ recorded on immunisation card Least marginalised 38% 43% 45% 55% -4.9% <0.01 Closing of equity gap
Most marginalised 29% 34% 39% 40% 3.5%
Nutrition
Frontline worker advised exclusive breastfeeding Least marginalised 50% 49% 33% 30% 1.1% 0.629
Most marginalised 39% 32% 42% 27% 8.7%
Immediate breastfeeding Least marginalised 51% 43% 52% 48% -4.9% <0.01 Reversal of equity gap
Most marginalised 43% 43% 57% 47% 10.4%
Initiation of complementary feeding Least marginalised 65% 64% 68% 61% 5.6% 0.239
Most marginalised 68% 61% 71% 60% 4.8%
Postnatal care
FLW advised skin-to-skin care Least marginalised 36% 46% 37% 26% 21.2% 0.064
Most marginalised 33% 28% 38% 22% 10.2%
FLW visited day or next of delivery / Return from hospital Least marginalised 21% 16% 5% 3% -2.8% 0.369
Most marginalised 19% 15% 10% 5% 0.9%
FLW visited within 1 week after delivery Least marginalised 27% 19% 10% 4% -2.4% 0.083
Most marginalised 23% 19% 13% 7% 1.7%
Skin-to-skin care Least marginalised 18% 24% 46% 32% 20.4% 0.018 Widening of equity gap
Most marginalised 17% 14% 42% 24% 14.8%

*By false discovery rate (FDR) adjustment for family-wise error of the P values in difference-in-difference analysis.

†Adjusted for women’s age and gender of focal child.

‡Diphtheria-pertussis-tetanus (DPT3).



CHS data

Among the 18 indicators analysed for CHS comparing the most marginalised to the least marginalised (as referent), most demonstrated disparity in frequency of behaviours between the two groups across rounds (Figure 3, Table 4). Specifically, the OR between the most and least marginalised groups was significant for six indicators, primarily in antenatal care, birth preparedness and delivery-related indicators. During program implementation, indicators (n = 7) that showed consistently lower odds across rounds for the most marginalised group included 4+ ANC visits (OR range: 0.08 to 0.20), arranged transportation to facility (OR range: 0.40 to 0.64), sought care for complications (OR range: 0.26 to 0.64), delivery in a facility (OR range: 0.15 to 0.48), delivery by a qualified doctor (OR range: 0.08 to 0.25), receipt of DPT3 (OR range: 0.41 to 0.9), and initiation of complementary feeding (OR range: 0.34 to 0.94). Four indicators showed consistently higher odds for the most marginalised group: pregnancy registration (OR range: 1.68 to 6.3), identification of a skilled birth attendant (OR range: 1.25 to 2.72), immediate breastfeeding (OR range: 1.05 to 1.82) and FLW visited the day of or the day after delivery (OR range: 1.54 to 1.99).

Figure 3.  Comparison of the disparity across Community-based Household Surveys (CHS) indicators favouring the most marginalised vs the least marginalised, by round, Bihar, India, 2012-2017. ANC – antenatal care, DPT – diphtheria-pertussis-tetanus (DPT3), FLW – frontline worker, IFA – iron-folic acid, PPIUD – postpartum intrauterine device.
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Table 4.  Comparison of Community-based Household Survey (CHS) indicators between the least and most marginalised by round 2-9, Bihar, India, 2012-2017*,†
Indicator Round 2 Round 3 Round 4 Round 5 Round 6 Round 7 Round 8 Round 9
Antenatal care
4+ antenatal care visits 0.11 (0.05-0.25) N/A‡ N/A 0.14 (0.08-0.27) 0.08 (0.05-0.15) 0.14 (0.09-0.21) 0.1(0.06-0.17) 0.2 (0.13-0.31)
Identified skilled birth attendant 1.43 (0.81-2.53) 1.58 (0.98-2.56) 1.4 (0.86-2.25) 1.57 (0.98-2.52) 1.79 (1.17-2.74) 2.13 (1.39-3.27) 2.72 (1.76-4.20) 1.25 (0.77-2.04)
Arranged transport to facility 0.47 (0.28-0.77) 0.41 (0.25-0.69) 0.64 (0.34-0.88) 0.54 (0.34-0.88) 0.57 (0.38-0.86) 0.4 (0.27-0.60) 0.56(0.37-0.85) 0.61(0.39-0.95)
Sought care for complications N/A N/A 0.51 (0.24-1.11) N/A 0.64 (0.30-1.40) 0.33 (0.21-0.52) 0.26 (0.17-0.42) 0.43 (0.28-0.66)
Pregnancy registration 1.68 (1.02 -2.76) 2.12 (1.27-3.55) N/A N/A 2.89 (1.89-4.41) 6.3 (3.85-10.31) 3.76 (2.28-6.21) 3.72 (2.02-6.85)
Received iron-folic acid tablets 1.03 (0.67-1.58) 0.92 (0.60-1.40) 1.12 (0.74-1.70) 1.46 (0.96-2.23) 1.45 (1.00-2.10) 1.47 (1.05-2.09) 0.8 (0.54-1.18) 1.1 (0.76-1.60)
Frontline worker (FLW) advised hand-washing by attendant 0.85 (0.49-1.47) 1.78 (1.05-3.02) 1.02 (0.60-1.76) 1.49 (0.85-2.62) 0.92 (0.55-1.52) 1.4 (0.81-2.42) 1.78 (0.98-3.25) 1.33 (0.78-2.27)
Delivery
Delivery in a facility (public or private) 0.22 (0.12-0.41) 0.48 (0.29-0.81) 0.17 (0.10-0.32) 0.24 (0.13-0.43) 0.27 (0.16-0.47) 0.15 (0.09-0.26) 0.18 (0.10-0.31) 0.21 (0.13-0.35)
Facility delivery by Qualified Doctor 0.25 (0.12-0.49) 0.22 (0.11-0.43) N/A 0.08 (0.04-0.18) 0.12 (0.07-0.20) 0.16 (0.09-0.28) 0.10 (0.05-0.19) N/A
Family planning
FLW advised adoption of PPIUD 0.85 (0.39-1.85) 0.93 (0.49-1.79) 0.47 (0.24-0.90) 1.25 (0.62-2.48) 0.45 (0.25-0.81) 1.46 (0.67-3.15) 1.81 (0.86-3.85) 0.57 (0.29-1.12)
FLW advised adoption of sterilisation 1.24 (0.67-2.33) 1.21 (0.66-2.22) 0.66 (0.36-1.22) 2.52 (1.37-4.64) 0.73 (0.42-1.27) 2.21 (1.06-4.60) 1.4 (0.73-2.70) 1.09 (0.59-2.03)
Immunisation
DPT3 recorded on immunisation card 0.41 (0.27-0.62) 0.9 (0.63-1.35) 0.51 (0.33-0.81) 0.63 (0.42-0.96) 0.48 (0.33-0.69) N/A N/A N/A
Nutrition
Initiation of complementary feeding 0.92 (0.61-1.38) 0.94 (0.62-1.43) 0.39 (0.21-0.75) 0.46 (0.22-0.94) 0.91 (0.60-1.38) 0.34 (0.19-0.59) 0.52 (0.35-0.75) 0.34 (0.20-0.55)
Immediate breastfeeding 1.3 (0.86-1.98) 1.35 (0.90-2.03) 1.82 (1.20-2.76) 1.42 (0.94-2.17) 1.8 (1.25-2.59) 1.74 (1.23-2.47) 1.75 (1.22-2.50) 1.05 (0.68-1.64)
FLW advised exclusive breastfeeding 0.63 (0.35-1.13) 0.84 (0.48-1.47) 0.86 (0.49-1.50) 1.52 (0.84-2.75) 0.66 (0.39-1.11) 0.98 (0.57-1.66) 1.33 (0.72-2.44) 1.11 (0.66-1.87)
Postnatal care
Skin-to-skin care 1.14 (0.64-2.05) 0.9 (0.53-1.54) 0.64 (0.37-1.10) 1.32 (0.81-2.15) 1.53 (0.96-2.45) 2.16 (1.21-3.89) 1.31 (0.82-2.08) 1.71 (1.06-2.75)
FLW advised skin-to-skin care 0.76 (0.42 -1.36) 1.13 (0.65-1.95) 1.09 (0.63-1.89) 1.35 (0.77- 2.38) 1.18 (0.68-2.08) 1.1 (0.57-2.12) 1.27 (0.68-2.41) 1.08 (0.62-1.90)
FLW visited within 1 week after delivery 0.9 (0.59-1.36) 1.38 (0.92-2.08) 1.14 (0.76-1.71) 2.99 (1.95-4.59) 1.69 (1.15-2.49) 2.06 (1.43-2.98) 2.52 (1.69-3.74) 1.28 (0.89-1.84)

DPT – diphtheria, pertussis, tetanus; PPIUD – postpartum intrauterine device

*Adjusted for women’s age and gender of focal child.

†Expressed as an odds ratio comparing the most to the least marginalised women as referent, with 95% confidence interval.

‡Number of women in the subgroups of either the least or most marginalised group for the indicator was less than 10 and thus was not reported in this table.



No significant linear trends of the ORs over rounds were found for any of the indicators. Generally there were no significant changes in linear trends for the most marginalised across indicators assessed and thus, any changes in disparity were driven by changes in trends for the least marginalised (Figure S2 in the Online Supplementary Document). For three indicators, improvement in the behaviours of the least marginalised led to increased disparity compared to the most marginalised, including delivery by a qualified doctor, initiation of complementary feeding, and receipt of DPT3 (Table 5). For four indicators, a decrease in the behaviour by the least marginalised group led to increased disparity favouring the most marginalised, including pregnancy registration, identification of a skilled birth attendant, visit by a FLW within one week of delivery, and immediate breastfeeding. Disparity persisted but trends did not change over time for 4+ ANC visits, arrangement of transportation to a facility, facility delivery, and seeking care for complications. There were no significant disparities observed for indicators related to FLW-delivered advice, as well as skin to skin care and receipt of iron-folic acid (IFA).

Table 5.  Categorisation of trends over time for least marginalized* compared to the most marginalised† based on Community-based Household Survey (CHS) data, Bihar, India (2012-2017)
Increased disparity due to least marginalised improvement: Increased disparity due to least marginalised worsening:
• Delivery by a qualified doctor
• Initiation of complementary feeding
• Receipt of diptheria, pertussis, tetanus (DPT)3 • Pregnancy registration
• Identified skilled birth attendant
• Immediate breastfeeding
• Frontline worker (FLW) visited within 1 week of delivery
Disparity stable over time, favoring least marginalized: No disparity, no significant changes over time:
• 4+ antenatal care visits
• Arranged transport to facility
• Sought care for complications
• Facility delivery • Received iron-folic-acid tablets
• Skin-to-skin care
• FLW advised handwashing
• FLW advised post-partum intrauterine device
• FLW advised sterilisation
• FLW advised breastfeeding
• FLW advised skin to skin care

*Least marginalised (LM) defined as General/Other/highest wealth tertile.

†Most marginalised (MM) defined as SCST/lowest wealth tertile.



DISCUSSION

The Ananya program aimed to improve the health of women across Bihar through governmental delivery of RMNCHN interventions by means of FLW outreach, improved health messaging, and improved facility-based care. At baseline, women’s behaviours often did not adhere to recommendations for continuum of care services which have been proven effective for reductions in maternal and neonatal morbidity. The program aimed to improve this, with varying success [21,22,30,31]. In this analysis, we aimed to assess whether there were disparities in impact for these RMNCHN indicators throughout the course of implementation, for those women who were most marginalised compared to the least marginalised.

With regard to the two groups assessed, we found that generally the most marginalised women were older, less literate or educated, had more children and a nuclear family. A female focal child was also more likely to have a mother in the most marginalised group.

The results of our equity analysis demonstrated that there were disparities in many health-related behaviours between the most and least marginalised mothers at baseline in 2012, and for the most part these disparities persisted throughout the study period. CHS data suggested that the largest disparities favouring the least marginalised were observed for those indicators dependent on access to care, such as delivery in a facility, arrangement of transportation to a facility, and seeking care for complications. For some indicators, improvements were seen for the least marginalised over time, which were not seen for the most marginalised, thus leading to increases in disparities. These indicators included delivery by a qualified doctor, initiation of complementary feeding and receipt of DPT3, and thus could also be considered as related to access to care or to varied food sources. In contrast, indicators that demonstrated improvements in equity over time typically were behaviours that were driven primarily by maternal choice such as registration of pregnancy, identification of a skilled birth attendant, and immediate breastfeeding. Given that there were no significant disparities observed for indicators related to FLW advice between the two groups, the CHS data suggest that inequities were more likely due to access to care rather than to differences in exposure to health messaging.

These findings align with prior studies suggesting that interventions delivered through health facilities, such as skilled birth attendance and ANC visits are significantly more prone to inequity than community-based interventions or those initiated by individual agency such as breastfeeding [5,13]. The drivers of these findings are likely multifactorial, and include individual-level issues of access (including geographic, social and financial barriers to access such as time poverty and household support), system-level issues of inadequate health financing, limited human resources, and social determinants of health such as discrimination driven by caste and economic disadvantage [6].

The Mathematica data suggests a more mixed picture, although notably the midline data was collected only two years after program implementation began. Similar to the CHS data, the most marginalised group demonstrated greater improvement in immediate breastfeeding. In contrast to CHS data, greater improvements were seen in the least marginalised women in maternal behaviours of skin-to-skin care and identification of a skilled birth attendant. Those who were most marginalised had increased improvement in DPT3 rates. These improvements of the most marginalised are consistent with prior studies which report the least inequities in impact for breastfeeding and immunisation rates [4,5,11].

There are several limitations to this study. All data sets relied on women’s self-reported behaviours and thus are at risk for response and social desirability biases. Second, women were surveyed from different geographical areas, and thus may have had varying exposures to program interventions and there may have been cluster effects amongst communities of women. Furthermore, while the Mathematica survey was the most rigorous of the evaluations conducted as surveys were administered by evaluators who were independent of implementation and the data are further strengthened by its DID framework, data collection occurred after a relatively short, two-year period of program implementation. The CHS surveys, on the other hand, were collected over six years of implementation but were intended to be used for internal monitoring information rather than for program evaluation. Therefore, they were collected without a comparison group and thus could not account for secular improvements in the indicators occurring concurrently. Further, the round 2 survey was collected after implementation of some interventions had already begun and thus did not serve as a true baseline.

The most notable limitation in our equity analysis was its narrowed scope of comparison to the least and most marginalised groups, or the extreme ends of the equity spectrum rather than across the intermediary groups, due to the challenges inherent in an intersectionality approach. As a term, “intersectionality” focuses on the ways in which interactions of multiple social determinants and inequalities lead to health inequities [20,32-34]. However, there is no agreement in the literature on how to prioritise across contributing sociodemographic and economic variables; rather, intersectionality “rejects hierarchical ordering of oppression” [35]. Therefore, the ordering of these intermediary groups would be impacted by the varying contributions of individual contextual factors over time and across geographic settings, and would also differ across indicators [36,37]. For that reason, this analysis focused on those subcategories which were defensibly at the ends of the spectrum, enabling us to elucidate more reliably how socioeconomic inequalities influence the impact of the program across indicators, time and geography.

Despite these limitations, the results suggest that the Ananya program had variable impact on the inequity that existed at baseline between the least and most marginalised groups across the continuum of care and delivery platforms. While disparities were observed across most health-related behaviours – and these disparities generally persisted over time – there were significant increases in inequity between these two groups, most notably among those indicators reliant upon access to care. Examination of reasons for this in the context of Bihar is warranted as part of a comprehensive effort to reduce health inequities, which could include increased investment in improving contributing factors such as affordability, accessibility and quality of care, including dignified treatment and gender equality [6,10,14]. From an equity perspective, evidence from the literature also suggests that strengthening community-based care may be beneficial. A review by Schleiff et al. analysed the equity effects of programs utilising community-based primary health care and found that community-based projects had greater success in decreasing inequity for maternal and child health due to their accessibility when compared to projects that strengthened services at facilities [13].

By providing support across FLW outreach, community and facility-based platforms, the Ananya program intended to improve health for all Bihari women similar to that of a universal health approach. We show that the program’s impacts were largely seen in the improvement or worsening of indicators among the least marginalised, with relatively little changes amongst the most marginalised. These findings suggest that some health interventions, like those delivered through health facilities, may have been inaccessible to, or could not be acted upon by those who were most disadvantaged. On the contrary, those facets of the Ananya program in which the most marginalised women were specifically identified and targeted, such as the Parivartan self-help group program, demonstrated successful results [30,31]. In Parivartan, self-help groups were leveraged to empower hard-to-reach and marginalised women, which led to significant improvements across RMNCHN indicators.

Together, this body of data demonstrates the importance of recent calls for universal health programs to assess equity impacts [5,6,14], as programs that take an equity blind approach in their implementation may be at risk for perpetuating or even exacerbating inequities. Instead, underlying disparities must be measured and addressed, even targeted, with progress monitored throughout implementation. Additional research may be required, including mixed methods approaches, to understand the contributing factors and underpinning reasons for inequities, and to monitor programmatic impact on the most marginalised groups as well as across intermediary groups. Only then can large-scale health interventions ensure that they are closing gaps of disparity, and thus upholding the SDGs’ call to “leave no one behind.”

CONCLUSION

While there is an ever-increasing armamentarium of evidence-based RMNCHN interventions, these interventions require further evaluation through an equity lens. Advances will not achieve sustainable benefits for future generations without ensuring that sub-populations that differ along intersecting axes of social determinants of health also benefit equitably. Further, these analyses must inform the adoption and implementation of programs and policies worldwide. This will not only require increased funding, but also political investment in equity. As noted by Alkebrack et al., greater political commitment through government spending is the biggest predictor of health equity [38]. Governments must be willing to invest in equity-oriented systems to promote inclusive health advancements.

As we advance technology, expand the evidence for cost-effective interventions, and scale-up RMNCHN in LMICs, it will be important to focus on rigorous study of disparities in health indicators between subgroups, and the factors underlying these disparities. This will ensure that investments in global health benefit all communities, particularly those who may need them the most.

Additional material
Acknowledgements

The Learning from Ananya Research Theme paper collection is dedicated to Ms Usha Kiran Tarigopula of the India Country Office of the Bill and Melinda Gates Foundation. Her tireless efforts to improve the health of India’s most marginalized women and children, and her steadfast leadership in using evidence to improve program implementation made this learning possible. We acknowledge the contribution of the Stanford University Quantitative Statistical Unit for their review of the results and input into presentation of this study. We also acknowledge the efforts of CARE India and Mathematica for their collection and management of the data, as well as their input on this analysis.

Notes

[1] Funding: This study was supported by grants from the BMGF, including: OPP1163688 to Stanford University, OPP1084426 to CARE India, and OPP 20210 to Mathematica. BMGF India Country Office program officers reviewed the manuscript for accuracy and adequate description of the interventions, study design, and data collection, however, the senior author had full access to the data and independence from the funders in the reporting of results, the interpretation of the data and the decision to publish the manuscript.

[2] Authorship contributions: The analyses in this manuscript were conceived by JB, YW, YA, VW, SC, KM and GLD, with GLD serving as the study’s principal investigator. Data analysis was conducted by JB, YW and SC. All authors participated in discussion about the analysis plan and results. VW, JB and YW drafted the first draft manuscript, and all contributing authors reviewed, provided input and approved the final draft for submission.

[3] Competing interests: The authors have completed the ICMJE Unified Competing Interest form (available on request from the corresponding author) and declare no other competing interests.

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