What are the risk factors for death among children with pneumonia in low- and middle-income countries? A systematic review

Background Knowledge of the risk factors for and causes of treatment failure and mortality in childhood pneumonia is important for prevention, diagnosis, and treatment at an individual and population level. This review aimed to identify the most important risk factors for mortality among children aged under ten years with pneumonia. Methods We systematically searched MEDLINE, EMBASE, and PubMed for observational and interventional studies reporting risk factors for mortality in children (aged two months to nine years) in low- and middle-income countries (LMICs). We screened articles according to specified inclusion and exclusion criteria, assessed risk of bias using the EPHPP framework, and extracted data on demographic, clinical, and laboratory risk factors for death. We synthesized data descriptively and using Forest plots and did not attempt meta-analysis due to the heterogeneity in study design, definitions, and populations. Findings We included 143 studies in this review. Hypoxaemia (low blood oxygen level), decreased conscious state, severe acute malnutrition, and the presence of an underlying chronic condition were the risk factors most strongly and consistently associated with increased mortality in children with pneumonia. Additional important clinical factors that were associated with mortality in the majority of studies included particular clinical signs (cyanosis, pallor, tachypnoea, chest indrawing, convulsions, diarrhoea), chronic comorbidities (anaemia, HIV infection, congenital heart disease, heart failure), as well as other non-severe forms of malnutrition. Important demographic factors associated with mortality in the majority of studies included age <12 months and inadequate immunisation. Important laboratory and investigation findings associated with mortality in the majority of studies included: confirmed Pneumocystis jirovecii pneumonia (PJP), consolidation on chest x-ray, pleural effusion on chest x-ray, and leukopenia. Several other demographic, clinical and laboratory findings were associated with mortality less consistently or in a small numbers of studies. Conclusions Risk assessment for children with pneumonia should include routine evaluation for hypoxaemia (pulse oximetry), decreased conscious state (e.g. AVPU), malnutrition (severe, moderate, and stunting), and the presence of an underlying chronic condition as these are strongly and consistently associated with increased mortality. Other potentially useful risk factors include the presence of pallor or anaemia, chest indrawing, young age (<12 months), inadequate immunisation, and leukopenia.

Background Knowledge of the risk factors for and causes of treatment failure and mortality in childhood pneumonia is important for prevention, diagnosis, and treatment at an individual and population level.This review aimed to identify the most important risk factors for mortality among children aged under ten years with pneumonia.
Methods We systematically searched MEDLINE, EMBASE, and PubMed for observational and interventional studies reporting risk factors for mortality in children (aged two months to nine years) in low-and middle-income countries (LMICs).We screened articles according to specified inclusion and exclusion criteria, assessed risk of bias using the EPHPP framework, and extracted data on demographic, clinical, and laboratory risk factors for death.We synthesized data descriptively and using Forest plots and did not attempt meta-analysis due to the heterogeneity in study design, definitions, and populations.

Findings
We included 143 studies in this review.Hypoxaemia (low blood oxygen level), decreased conscious state, severe acute malnutrition, and the presence of an underlying chronic condition were the risk factors most strongly and consistently associated with increased mortality in children with pneumonia.Additional important clinical factors that were associated with mortality in the majority of studies included particular clinical signs (cyanosis, pallor, tachypnoea, chest indrawing, convulsions, diarrhoea), chronic comorbidities (anaemia, HIV infection, congenital heart disease, heart failure), as well as other non-severe forms of malnutrition.Important demographic factors associated with mortality in the majority of studies included age <12 months and inadequate immunisation.Important laboratory and investigation findings associated with mortality in the majority of studies included: confirmed Pneumocystis jirovecii pneumonia (PJP), consolidation on chest x-ray, pleural effusion on chest x-ray, and leukopenia.Several other demographic, clinical and laboratory findings were associated with mortality less consistently or in a small numbers of studies.
Conclusions Risk assessment for children with pneumonia should include routine evaluation for hypoxaemia (pulse oximetry), decreased conscious state (e.g.AVPU), malnutrition (severe, moderate, and stunting), and the presence of an underlying chronic condition as these are strongly and consistently associated with increased mortality.Other potentially useful risk factors include the presence of pallor or anaemia, chest indrawing, young age (<12 months), inadequate immunisation, and leukopenia.We categorised context, population and outcome data, then qualitatively synthesised results to determine the consistently reported risk factors for mortality in children with pneumonia including summary data on odds ratios and case fatality rates.To account for the possibility of type 1 or type 2 errors clouding the true significance of factors that were only analysed in a small number of studies, we disaggregated results to show which factors were examined in at least four studies.We focus our reporting on those factors that have been studied in at least four studies and found to be universally (in all studies) or consistently (in the majority of studies) associated with mortality.
We reported crude and adjusted estimates of associations with mortality, as per individual studies, recognising that there was variable use of odds ratios, risk ratios (relative risk), and hazards ratios.To enable comparison between studies we summarised crude estimates (usually odds ratio) for the risk factors identified to be most consistently and strongly associated with death reporting them as median and range.We did not attempt meta-analysis as our primary goal was to understand treatment outcomes with respect to a range of risk factors with variability in definition and heterogeneity in population and context.We did not attempt quantitative examination of heterogeneity or certainty but reported all outcomes of interest by individual study in supplemental material for completeness and transparency.
In addition to mortality as a hard endpoint of treatment failure, we also reviewed other treatment failure endpoints (variously defined as clinical deterioration requiring a change in management, or persistence of particular symptoms), hypoxaemia (an objective sign of respiratory failure), and the need for high dependency unit / intensive care unit (HDU / ICU) admission.

Assessment of study quality and risk of bias
We assessed the quality and risk of bias of all included studies by using the Effective Public Health Practice Project (EPHPP) Quality Assessment Tool [7,8].Two reviewers (CW and MB) independently rated studies as strong, moderate, or weak with respect to selection bias, study design, confounders, blinding, data collection method, withdrawals and dropouts, and a global rating.Where disagreements occurred, a third reviewer (HG) carried out a final assessment.
We report our findings according to PRISMA and SWiM standards [9,10].

RESULTS
A total of 8492 references were retrieved through the search, and two additional relevant papers were identified on review of references.After duplicates were removed 5687 references were screened, including full text screening of 283 publications.We excluded 140 papers on full text review (Text S2 in the Online Supplementary Document), primarily due to lack of relevant data on risk factors (n = 59) or not relating to children with pneumonia (n = 50) (Figure 1).We included 143 studies in qualitative synthesis .

Characteristics of studies
Included study details and participant characteristics are reported in Table 1 and details are presented in Table S4 in the Online Supplementary Document.Papers were included from all WHO regions and all World Bank income levels, including 36 (25%) studies involving low-income countries (LICs), 70 (49%) LMICs, and 53 (37%) upper-middle income countries (UMICs).One hundred and thirty-six (95%) studies were observational, including prospective and retrospective cohort studies, cross-sectional studies, case-control studies, surveillance studies, with seven (5%) interventional studies.Study quality was typically low to moderate with seven (5%) studies rating as "strong" on EPHPP (Table S1 in the Online Supplementary Document).Thirty-five (25%) studies addressed risk factors for mortality in childhood pneumonia as their primary aim.

DISCUSSION
Number of child participants in each study ranged from 40 to 113 154 (median = 519).Median age ranged from three to 65 months and most studies (n = 83 / 92, 90%) that reported the participant sex included more males than females (percentage of males ranged from 44.50% to 71.70%).Vaccination status was reported in 23 (16%) studies, with 52% to 97% of children fully vaccinated according to national schedules.Many studies were conducted prior to introduction of Hib or pneumococcal conjugate vaccine (PCV) and there was enormous variability in PCV and Hib vaccination status (from 0.00 to 99.40%).Case fatality rates ranged from 0.20% to 56.30% which in part reflects different inclusion criteria and context of the different studies, with some including all pneumonia patients, some only including severe pneumonia patients, and some only patients admitted to ICU.

Risk factors for mortality
Table 2 summarises the demographic, clinical, and laboratory factors investigated for association with mortality in included studies, restricted to factors reported in at least four studies.Additional factors studied in three or fewer studies are reported in Tables S2a-S2d in the Online Supplementary Document.Most risk factors of interest were reported in a small minority of studies, with only two demographic (age, sex), seven clinical (hypoxaemia, HIV infection, WHO severe pneumonia, severe malnutrition, comorbidities, tachypnoea), and two laboratory or aetiology (viral, bacterial) risk factors reported in more than 10% of included studies.

Demographic and household factors
The demographic factors found to be most clearly associated with pneumonia mortality included younger age and inadequate immunization (Table 2).Data from 27 / 41 (66%) studies reporting on risks of death by age showed higher risk of death for younger children.Children aged under one year of age had a 2.5-fold higher risk of death (range from 1.4 to 29) than children aged one-four years and risk of death for infants under six months of age was particularly high.Fewer studies reported on the association between immunisation status and pneumonia mortality (n = 14), suggesting that under-immunised children have a 3-fold higher risk of death (range from 1.6 to 12.3) than fully immunised.
Female sex, inadequate breastfeeding, lower parental education level, lower socio-economic status, smoking exposure at home, and indoor pollution at home were all examined in at least four studies and found to be associated with mortality in up to half of those studies (Table 2).Data from eight studies reported that children from poorer families had a 2-fold higher risk of death (range from 2.2 to 2.9) than children from wealthier families, with similar increased risk for those with low parental education level compared to higher education (range from 1.4 to 4.4).Half the studies reporting smoking at home (n = 3 / 6) or indoor air pollution (n = 2 / 4) found an association with increased mortality.Suboptimal breastfeeding was found to be associated with mortality in infants with pneumonia in 4 / 7 (43%) of studies with fold higher risk of death (range from 1.7 to 4.4).Girls with pneumonia were found to have an approximate 30% increased risk of death compared to boys with a positive association between sex and mortality reported in one-quarter or 25% of studies (n = 9 / 36) that evaluated an association.This association between sex and mortality was found in diverse studies from Africa, Asia, and South America, with the elevated risk of death typically remaining after adjusting for other factors (e.g.age).Crowding at home was examined in four studies which did not find an association with pneumonia mortality.
Other demographic factors that were found to be associated with mortality in at least one study but reported in three or fewer studies included: low maternal age, past experience of child loss, living in a malaria endemic area, poor quality drinking water, late referral, lack of adequate sewage or latrine at home, and living in   CFR -case fatality rate, CRP -C-reactive protein, CXR -chest x-ray, HFAZ -height for age z-score, HIV -human immunodeficiency virus, HR -hazards ratio , OR -odds ratio, RR -risk ratio, RSV -respiratory syncytial virus, SpO 2 -peripheral blood oxygen saturation, WCC -white cell count, WFAZ -weight for age z-score, WFHZ -weight for height z-score, WHO -World Health Organization *Median OR/RR/HR and CFR reported where available, with ranges if reported in more than a single study.†Estimates restricted to studies which defined hypoxaemia as SpO 2 <90%.‡WHO severe pneumonia includes a composite of any of the following clinical signs: SpO 2 <90%, severe respiratory distress, altered conscious state, unable to feed/drink, convulsions, severe malnutrition, severe anaemia/pallor.§Tachycardia typically defined as heart rate >160/minutes aged <12 months, >120/minutes aged 1-4 years, >100/minutes aged over 5 years.‖Tachypnoea typically defined by age-specific respiratory rate: ≥60 aged <2 months, ≥50 aged 2-11 months, ≥40 aged 1-4 years, and ≥30 aged over 5 years.¶Predominate negative association with mortality.**Mixed positive and negative association.
a rural area (Table S2a and Table S3a in the Online Supplementary Document).Antenatal care and birth spacing was only examined in one study and was associated with a lower risk of mortality.

Clinical factors
The clinical signs that were most clearly and strongly associated with mortality were decreased conscious state, hypoxaemia, cyanosis, malnutrition, severe pallor, and the presence of comorbid conditions (including HIV infection) (Table 2).Decreased conscious state was found to be associated with increased risk of death in all 12 studies that reported, associated with 7-fold higher risk of death (range from 3.1 to 324), with similar estimates from the fewer studies reporting on convulsions (Figure 2, panel A).Severe hypoxaemia (SpO 2 <90%) was associated with a 5.5-fold increased risk of death (range from 1.8 to 48.1) in 32 / 34 (94%) studies that reported it, while less severe hypoxaemia (e.g.SpO 2 = 90%-93%) was also consistently associated with mortality (Figure 2, panel B, Table S3b in the Online Supplementary Document).Severe acute malnutrition (based on weight for age / height) was found to increase risk of death 5-fold, while moderate wasting and stunting were also consistently associated with a 2-fold increase in risk of death (Figure 3, panel A and panel B, Table 2).The WHO "severe pneumonia" classification (cough or difficult breathing with hypoxaemia, SpO 2 <90%, or any danger sign -altered conscious state, convulsions, inability unable to feed/drink), was associated with a 4-fold increase in risk of death in 27 / 29 studies that reported it.
The presence of any chronic condition or comorbidity increased risk of death 5-fold (range from 1.9 to 18), with particular conditions such as congenital heart disease, HIV infection, neurodevelopmental conditions, anaemia, pre-term / low birth weight, being of particular concern.Conversely, the presence of asthma (or wheeze) was generally found to be associated with lower risk of death, with mixed findings about the impact of malaria co-infection.The presence of tachypnoea (fast breathing), diarrhoea, chest indrawing, and positive findings on chest auscultation were each found to be associated with a 2 to 3-fold increased risk of death.Fever and tachycardia were associated with increased risk of mortality in some studies, and decreased risk in others.Other clinical factors that were found to be associated with mortality in at least one study but reported in three or fewer studies included: hypothermia t < 36.50, hypotension, signs of shock, meningitis, previous pneumonia admission, maternal disease in pregnancy, maternal tuberculosis, sepsis and stridor (Table S2a and Table S3b in the Online Supplementary Document).

Clinical investigations and aetiology
We generally found weak or inconsistent associations with mortality for aetiology other investigations (Table 2).While some studies found increased risk of death from bacterial causes of pneumonia and / or decreased risk of death from viral causes, most studies that explored the contribution of bacterial vs viral aetiologies found no association with risk of death.Of the individual bacterial aetiologies, the presence of PJP was found to be associated with 4-fold increase in risk of death (range from 1.9 to 5.3), from a small number of studies (n = 4).Of the viral aetiologies, there is some evidence for increased risk of death from parainfluenza and decreased risk of death from respiratory syncytial virus (RSV) and human metapneumovirus.Consolidation or pleural effusion on chest x-ray (CXR) were associated with a 4-fold increased risk of death compared to children with normal CXR.Data from a small number of studies suggested that high white cell count (leucocytosis) was not associated with mortality but low white cell count (leukopenia) was associated with increased risk of death.We found mixed findings regarding the association between mortality and elevation in C-reactive protein (CRP), a widely used inflammatory marker.
Other aetiological or clinical investigation factors that were found to be associated with mortality in at least one study but were examined in three or fewer studies included: pneumococcus, staphylococcus, influenza A, influenza B, H1N1 influenza, pneumothorax on CXR, electrolyte abnormality, hypoglycaemia, hyperglycaemia, thrombocytopaenia, low zinc, high lactate, acidaemia, low serum bicarbonate, and various markers of infection or inflammatory response (high procalcitonin, high ESR, high IL-1RA, high IL-6, high IL-8, high IL-17, high MIP-1a, high CK-MB fraction, high copeptin, high angiopoietin 2:angiopoietin 1 ratio, low angiopoietin 1, and low CCL22) (Table S2a, Table S3e and Table S3f in the Online Supplementary Document).
Risk factors for other types of severe treatment failure Tables S2b-2d in the Online Supplementary Document summarise the associations between risk factors and hypoxaemia, intensive care unit (ICU) admission, and other forms of treatment failure for all factors in which the association with mortality was reviewed in at least four studies.Additional details are presented in Tables S3g-S3x in the Online Supplementary Document.
The numbers of papers reviewing these other endpoints was lower (which may reflect the search strategy's focus on the primary endpoint of mortality).While there was general concordance in whether different factors were associated each of these endpoints, there were some notable differences.For example, while girls tended to have higher mortality than boys, sex was not associated with hypoxaemia or treatment failure, and girls were less likely to be admitted to ICU than boys.Similarly, while viral aetiology (e.g.influenza, RSV) was associated with hypoxaemia, it was not associated with ICU admission or other treatment failure.Among the clinical risk factors, hypoxaemia, tachypnoea, chest indrawing, and the presence of comorbidities were all consistently associated with hypoxaemia, ICU admission, and other treatment failure.Malnutrition was not clearly associated with hypoxaemia but was associated with ICU admission and other treatment failure, perhaps indicating that children with malnutrition present with similar pneumonia severity but have worse disease progression and recovery.

DISCUSSION
Our systematic review identified important risk factors for treatment failure or mortality in children with pneumonia.We found many factors that may be associated with mortality, including demographic, maternal, socioeconomic, environmental, laboratory, and radiological factors.The most consistently demonstrated risk factors for child pneumonia death are almost all clinical -young age, inadequate immunization, hypoxaemia, altered conscious state, malnutrition, anaemia, and comorbid conditions.However, clinical risk factors were also the most commonly reported and it is possible that other less-studied risk factors could emerge as important in future studies.
Our findings share similarities to Sonego et al. (2015) review of risk factors for child pneumonia mortality [154].While Sonego et al. included studies as far back as 1988 (n = 61/77 were published before 2010), we focussed on recent studies (published since 2010), identifying many papers not included in the Sonego re-view and excluding some that the Sonego review included (mostly because they restricted to a narrow population, such as RSV or HIV-infected).Like our review, the Sonego review identified young age, comorbid chronic conditions, malnutrition, unimmunised status, and Pneumocystis jirovecii as major risk factors for child pneumonia death.Two of the major clinical risk factors we identified (hypoxaemia and altered conscious state) were not examined in the Sonego review, with a subsequent review focussed on hypoxaemia clearly confirming it as a major risk factor for death [155].Compared to the Sonego review, we found less consistent association between socio-economic status, smoking or indoor air pollution and child pneumonia mortality.Both our review and Sonego's review found evidence of girls with pneumonia having poorer outcomes than boys, possibly related to differential care-seeking and treatment practices, although results from individual studies were mixed.The Sonego review did not explore laboratory and radiological predictors of mortality or individual clinical signs.

Implications for policy and practice
Many child deaths are predictable based on a few specific risk factors and there are increasing calls to improve risk stratification of existing child health guidelines [1].Our review highlights risk factors for mortality among children with pneumonia and presents opportunities to improve current guidance and strategies for pneumonia control.
Current pneumonia control strategies identify particular priorities for protection (breastfeeding, supplemental feeding), prevention (immunization, handwashing, HIV-prevention, reduced household air pollution) and treatment (care seeking, case management, antibiotics, oxygen) [156].Our review supports an emphasis on prevention and treatment of malnutrition and the critical role of immunization and HIV-prevention.While factors such as indoor air pollution and breastfeeding did not emerge as major risk factors for death among children with pneumonia, they remain important in reducing pneumonia incidence in the first place.In addition, we urge added attention to the prevention and treatment of anaemia, and the identification and preventive management of other chronic conditions and comorbidities such as congenital and neurodevelopmental conditions.
In terms of diagnosis and treatment, our review highlights clear opportunities to improve the identification of children with pneumonia who are at high risk of death.First, while malnutrition and hypoxaemia are included in the WHO severe pneumonia classification, current clinical guidelines generally focus on severe forms -severe acute malnutrition (SAM) and SpO 2 <90%.Our review shows than even moderate malnutrition and hypoxaemia (SpO 2 <94%) are associated with increased mortality.Furthermore, conscious state, nutritional status, and blood oxygen levels are poorly assessed in routine clinical care.Routine pulse oximetry, anthropometric measurement (e.g.MUAC), and assessment of conscious state (e.g.AVPU) is critical to identify high-risk patients.
Second, chronic underlying health conditions are not routinely assessed in current treatment algorithms and guidelines, which have traditionally focused on acute infectious killers.Chronic conditions are common and important to be addressed in their own right [157], but should also be considered a major risk factor for children presenting with acute illness.So, while continued emphasis on particular conditions such as malnutrition, anaemia, and HIV infection is warranted, guidelines should also encourage routine identification of any chronic illness or comorbidity and recognise that this puts children at higher risk of poor outcome.
Third, anaemia is a major risk factor for death but is difficult to detect clinically with current WHO guidelines relying on the clinical finding of "severe pallor".Technology exists for point-of-care haemoglobin measurement, including non-invasive devices integrated with pulse oximetry [158].Increased access to low-cost point-of-care haemoglobin tools may be particularly useful in malaria-endemic settings where anaemia is particularly common and deadly.
Future research may further define the role of additional laboratory investigations, such as lactate or procalcitonin, in defined populations (e.g.HDU/ICU).
Improved risk assessment and stratification has potential benefits for patients, health care workers, and broader health systems and communities.Severely ill patients can benefit from more prompt and timely diagnosis and access to appropriate treatment.Healthcare workers can more easily decide where to care for patients (e.g.inpatient, outpatient, HDU/ICU), how frequently to monitor and review patients, and when to escalate therapy.Health managers can make better decisions about which populations should be cared for in what level of facility and allocate resources accordingly.The wider community can have greater confidence that their loved ones will be cared for according to need.

Limitations
We used broad search criteria to capture studies reporting a wide range of potential risk factors for child pneumonia death and included studies from diverse geographical contexts.However, the quality of included studies was generally low and many risk factors were only examined in a small number of studies and limited geographical contexts.For reporting integrity we have included all results in supplemental material but focused our results on risk factors that have been consistently reported in multiple studies.It is possible that risk factors that have not been well explored in the literature to date will emerge with more data.Most included studies were hospital based, with over-representation of large urban hospitals.A high proportion of pneumonia deaths in low-and middle-income countries happen outside of hospital and examining pneumonia at the community or primary care level may reveal different risk factors or risk estimates [1,5].Furthermore, by only comparing risk factors between patients who have already been admitted to hospital we risk over-or under-emphasising factors that are commonly used to decide about admission (e.g.chest indrawing).Most included studies used the WHO clinical case definition for pneumonia, with few including radiographic evidence or distinguishing pneumonia from conditions such as bronchiolitis or asthma.We know that clinical pneumonia overlaps in features with other common conditions, such as malaria, and this can result in both over-diagnosis and under-diagnosis [159].However, this represents the case mix reality faced in many health facilities in low-and middle-income countries where clinical features must be relied upon.Our study reviewed the association with mortality among patients with pneumonia, and therefore factors which increase the risk of acquiring pneumonia in the first place (and therefore lead to an increased lifetime risk of dying from pneumonia) may not be highlighted.

CONCLUSIONS
Many studies of children with pneumonia in LMICs have investigated the association between clinical factors and mortality.A smaller number of studies have investigated sociodemographic, epidemiological and laboratory factors and their relationship to mortality.Hypoxaemia (low blood oxygen level), decreased conscious state, severe acute malnutrition, and the presence of an underlying chronic condition were the risk factors most strongly and consistently associated with increased mortality in children with pneumonia.Additional important clinical factors that were associated with mortality in the majority of studies included particular clinical signs (cyanosis, pallor, tachypnoea, chest indrawing, convulsions, diarrhoea), chronic comorbidities (anaemia, HIV infection, congenital heart disease, heart failure), as well as other non-severe forms of malnutrition.Important demographic factors associated with mortality in the majority of studies included age <12 months and inadequate immunisation.Important laboratory and investigation findings associated with mortality in the majority of studies included: confirmed PJP, consolidation on chest x-ray, pleural effusion on chest x-ray, and leukopenia.Several other demographic, clinical and laboratory findings were associated with mortality less consistently or in a small numbers of studies.
Routine assessment of blood oxygen levels, nutritional status, conscious state and comorbidities are critical for effective risk assessment and clinical decision making.The strong association of HIV, anaemia, comorbidities, and malnutrition with mortality highlights the importance of good quality primary and preventative care, and early care seeking.Data availability: All relevant data is reported in the manuscript or supplemental material.Funding: This work was funded by a grant from the WHO to the MCRI.Employees of WHO contributed to the design and oversight of the reviews.Any views or opinions presented are solely those of the author and do not necessarily represent those of the WHO, unless otherwise specifically stated.

Figure 2 .
Figure 2. Forest plot showing the unadjusted odds ratios (OR) for death among children with pneumonia from studies in low and middle-income countries (LMICs), comparing those with and without altered conscious state in Panel A or hypoxaemia in Panel B.

Figure 3 .
Figure 3. Forest plot showing the unadjusted odds ratios (OR) for death among children with pneumonia from studies in low and middle-income countries (LMICs), comparing those with and without severe acute malnutrition in Panel A or moderate acute malnutrition in Panel B.

Table 1 .
Characteristics of included studies and

Table 1 . continued Author, year Study type Time period Setting Country (city or region)
ICU -intensive care unit, MV -mechanical ventilation, PICU -paediatric intensive care unit, IMSS -Instituto Mexicano de Seguro Social (eng.Mexican Institute of Social Security) *These studies had risk factor identification as an explicit objective.

Table 1 . continued Table 2 .
Associations of demographic, clinical, and laboratory factors with mortality, ranked by the proportion of studies finding an association (limited to factors reported in ≥4 studies)